Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol

Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol.

UNLABELLED Restraint stress exposures evoke progressively larger increases in 2-arachidonoylglycerol (2-AG) in limbic brain regions as the number of repetitions increases. The Porsolt swim test usually involves two swim exposures separated by 24 h, and we asked whether the 2-AG response differed between the first and second exposures. METHODS Four groups of male C57/Bl6N mice were studied: co...

Table of contents Volume 7 Issue 2

[Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol].

Marijuana has been used as a traditional medicine and a pleasure-inducing drug for thousands of years around the world, especially in Asia. Delta(9)-tetrahydrocannabinol, major psychoactive component of marijuana, has been shown to interact with specific cannabinoid receptors, thereby eliciting a variety of pharmacological responses in experimental animals and human. In 1990, the gene encoding ...

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Stress differentially affects fear conditioning in men and women.

Stress and fear conditioning processes are both important vulnerability factors in the development of psychiatric disorders. In behavioral studies considerable sex differences in fear learning have been observed after increases of the stress hormone cortisol. But neuroimaging experiments, which give insights into the neurobiological correlates of stress × sex interactions in fear conditioning, ...